Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin

Mitochondria constantly divide and fuse. Homotypic fusion of the outer mitochondrial membranes requires the mitofusin (MFN) proteins, a family of dynamin-like GTPases. MFNs are anchored in the membrane by transmembrane (TM) segments, exposing both the N-terminal GTPase domain and the C-terminal tail...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huang, Xiaofang, Zhou, Xin, Hu, Xiaoyu, Joshi, Amit S., Guo, Xiangyang, Zhu, Yushan, Chen, Quan, Prinz, William A., Hu, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699052/
https://ncbi.nlm.nih.gov/pubmed/29093165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708782114
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