Structures of human mitofusin 1 provide insight into mitochondrial tethering

Mitochondria undergo fusion and fission. The merging of outer mitochondrial membranes requires mitofusin (MFN), a dynamin-like GTPase. How exactly MFN mediates membrane fusion is poorly understood. Here, we determined crystal structures of a minimal GTPase domain (MGD) of human MFN1, including the p...

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Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Qi, Yuanbo, Yan, Liming, Yu, Caiting, Guo, Xiangyang, Zhou, Xin, Hu, Xiaoyu, Huang, Xiaofang, Rao, Zihe, Lou, Zhiyong, Hu, Junjie
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147005/
https://ncbi.nlm.nih.gov/pubmed/27920125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201609019
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