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Mechanism of RNA polymerase II stalling by DNA alkylation
Several anticancer agents that form DNA adducts in the minor groove interfere with DNA replication and transcription to induce apoptosis. Therapeutic resistance can occur, however, when cells are proficient in the removal of drug-induced damage. Acylfulvenes are a class of experimental anticancer ag...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5699039/ https://ncbi.nlm.nih.gov/pubmed/29087308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706592114 |
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