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Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin

RNA polymerase II (Pol II) is the central enzyme that transcribes eukaryotic protein-coding genes to produce mRNA. The mushroom toxin α-amanitin binds Pol II and inhibits transcription at the step of RNA chain elongation. Pol II from yeast binds α-amanitin with micromolar affinity, whereas metazoan...

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Pubblicato in:J Biol Chem
Autori principali: Liu, Xiangyang, Farnung, Lucas, Wigge, Christoph, Cramer, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949985/
https://ncbi.nlm.nih.gov/pubmed/29550768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002545
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