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Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin
RNA polymerase II (Pol II) is the central enzyme that transcribes eukaryotic protein-coding genes to produce mRNA. The mushroom toxin α-amanitin binds Pol II and inhibits transcription at the step of RNA chain elongation. Pol II from yeast binds α-amanitin with micromolar affinity, whereas metazoan...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5949985/ https://ncbi.nlm.nih.gov/pubmed/29550768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002545 |
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