The acute effect of beta‐guanidinopropionic acid versus creatine or placebo in healthy men (ABC‐Trial): A randomized controlled first‐in‐human trial

AIMS: Increasing evidence indicates that the ATP‐generating enzyme creatine kinase (CK) is involved in hypertension. CK rapidly regenerates ATP from creatine phosphate and ADP. Recently, it has been shown that beta‐guanidinopropionic acid (GPA), a kidney‐synthesized creatine analogue and competitive...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Karamat, Fares A., Horjus, Deborah L., Haan, Yentl C., van der Woude, Lisa, Schaap, Marianne C., Oudman, Inge, van Montfrans, Gert A., Nieuwland, Rienk, Salomons, Gajja S., Clark, Joseph F., Brewster, Lizzy M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698587/
https://ncbi.nlm.nih.gov/pubmed/28795416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13390
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