mDia1 senses both force and torque during F-actin filament polymerization

Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind with the barbed end of actin filaments through a ring-like structure assembled from dimerized FH2 domains. It has been hypothesized that force applied to formin may facilitate transition of the...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Yu, Miao, Yuan, Xin, Lu, Chen, Le, Shimin, Kawamura, Ryo, Efremov, Artem K., Zhao, Zhihai, Kozlov, Michael M., Sheetz, Michael, Bershadsky, Alexander, Yan, Jie
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698482/
https://ncbi.nlm.nih.gov/pubmed/29162803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01745-4
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