Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization

Formins are force-sensing proteins that regulate actin polymerization dynamics. Here, we applied stretching tension to individual actin filaments under the regulation of formin mDia1 to investigate the mechanical responses in actin polymerization dynamics. We found that the elongation of an actin fi...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Kubota, Hiroaki, Miyazaki, Makito, Ogawa, Taisaku, Shimozawa, Togo, Kinosita, Kazuhiko, Ishiwata, Shin’ichi
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2017
Fag:
Molecular Machines, Motors, and Nanoscale Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529311/
https://ncbi.nlm.nih.gov/pubmed/28746856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.012
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