Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

BACKGROUND: Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diap...

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Main Authors: Otomo, Takanori, Tomchick, Diana R., Otomo, Chinatsu, Machius, Mischa, Rosen, Michael K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948019/
https://ncbi.nlm.nih.gov/pubmed/20927343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012896
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