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Crystal Structure of the Formin mDia1 in Autoinhibited Conformation
BACKGROUND: Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diap...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948019/ https://ncbi.nlm.nih.gov/pubmed/20927343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012896 |
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