The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia

Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Di Tullio, Alessandro, Rouault-Pierre, Kevin, Abarrategi, Ander, Mian, Syed, Grey, William, Gribben, John, Stewart, Aengus, Blackwood, Elizabeth, Bonnet, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698422/
https://ncbi.nlm.nih.gov/pubmed/29162833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01834-4
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