All-Trans Retinoic Acid Promotes an M1- to M2-Phenotype Shift and Inhibits Macrophage-Mediated Immunity to Leishmania major

As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis. Macrophage phenotypes range from M1, which express NO-mediated microbial killing, to M2 macrophages that might help...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Vellozo, Natália S., Pereira-Marques, Sâmara T., Cabral-Piccin, Mariela P., Filardy, Alessandra A., Ribeiro-Gomes, Flávia L., Rigoni, Thaís S., DosReis, George A., Lopes, Marcela F.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698282/
https://ncbi.nlm.nih.gov/pubmed/29204144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01560
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