Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi. CD8 T-lymphocytes help to control infection, but apoptosis of CD8 T cells disrupts immunity and efferocytosis can enhance parasite infection within macrophages. Here, we investigate how apoptosis of activated CD8 T cells aff...

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Publicat a:Cell Death Dis
Autors principals: Cabral-Piccin, M P, Guillermo, L V C, Vellozo, N S, Filardy, A A, Pereira-Marques, S T, Rigoni, T S, Pereira-Manfro, W F, DosReis, G A, Lopes, M F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917666/
https://ncbi.nlm.nih.gov/pubmed/27195678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.135
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