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Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection
We investigated how apoptosis pathways mediated by death receptors and caspase-8 affect cytokine responses and immunity to Leishmania major parasites. Splenic CD4 T cells undergo activation-induced apoptosis, and blockade of FasL-Fas interaction increased IFN-γ and IL-4 cytokine responses to L. majo...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Society for Leukocyte Biology
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896658/ https://ncbi.nlm.nih.gov/pubmed/24072877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0912463 |
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