Inhibition of caspase-8 activity promotes protective Th1- and Th2-mediated immunity to Leishmania major infection

We investigated how apoptosis pathways mediated by death receptors and caspase-8 affect cytokine responses and immunity to Leishmania major parasites. Splenic CD4 T cells undergo activation-induced apoptosis, and blockade of FasL-Fas interaction increased IFN-γ and IL-4 cytokine responses to L. majo...

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Hlavní autoři: Pereira-Manfro, Wânia F., Ribeiro-Gomes, Flávia L., Filardy, Alessandra Almeida, Vellozo, Natália S., Guillermo, Landi V. C., Silva, Elisabeth M., Siegel, Richard M., DosReis, George A., Lopes, Marcela F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2014
Témata:
Host Defense & Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896658/
https://ncbi.nlm.nih.gov/pubmed/24072877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0912463
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