Induction of Systemic Autoimmunity by Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome/Endolysosome but Not Type I IFN

Type I IFN and nucleic acid-sensing TLRs are both strongly implicated in the pathogenesis of lupus with most patients expressing IFN-induced genes in peripheral blood cells and with TLRs promoting type I IFNs and autoreactive B cells. About a third of SLE patients, however, lack the IFN signature su...

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Publicado no:J Immunol
Main Authors: Pollard, K. Michael, Escalante, Gabriela M., Huang, Hua, Haraldsson, Katarina M., Hultman, Per, Christy, Joseph M., Pawar, Rahul D., Mayeux, Jessica M., Gonzalez-Quintial, Rosana, Baccala, Roberto, Beutler, Bruce, Theofilopoulos, Argyrios N., Kono, Dwight H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698107/
https://ncbi.nlm.nih.gov/pubmed/29055005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700332
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