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Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

In vitro evidence suggests that plasmacytoid dendritic cells (pDCs) are intimately involved in the pathogenesis of lupus. However, it remains to be determined whether these cells are required in vivo for disease development, and whether their contribution is restricted to hyperproduction of type I I...

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Detalhes bibliográficos
Main Authors: Baccala, Roberto, Gonzalez-Quintial, Rosana, Blasius, Amanda L., Rimann, Ivo, Ozato, Keiko, Kono, Dwight H., Beutler, Bruce, Theofilopoulos, Argyrios N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581947/
https://ncbi.nlm.nih.gov/pubmed/23382217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222798110
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