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Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7, -9) signaling, we show these endosomal TLRs are required for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of disease in 2 lupus strains, B6-Fas...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715524/ https://ncbi.nlm.nih.gov/pubmed/19574451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905441106 |
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