Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7, -9) signaling, we show these endosomal TLRs are required for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of disease in 2 lupus strains, B6-Fas...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kono, Dwight H., Haraldsson, M. Katarina, Lawson, Brian R., Pollard, K. Michael, Koh, Yi Ting, Du, Xin, Arnold, Carrie N., Baccala, Roberto, Silverman, Gregg J., Beutler, Bruce A., Theofilopoulos, Argyrios N.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715524/
https://ncbi.nlm.nih.gov/pubmed/19574451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905441106
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires