Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions

[Image: see text] A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of MMPs are unique to each family...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Alford, Vincent M., Kamath, Anushree, Ren, Xiaodong, Kumar, Kunal, Gan, Qianwen, Awwa, Monaf, Tong, Michael, Seeliger, Markus A., Cao, Jian, Ojima, Iwao, Sampson, Nicole S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697452/
https://ncbi.nlm.nih.gov/pubmed/28945333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00758
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