XRCC1-mediated repair of strand breaks independent of PNKP binding

Repair of DNA-protein crosslinks and oxidatively damaged DNA base lesions generates intermediates with nicks or gaps with abnormal and blocked 3′-phosphate and 5′-OH ends that prevent the activity of DNA polymerases and ligases. End cleaning in mammalian cells by Tdp1 and PNKP produces the conventio...

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Gepubliceerd in:DNA Repair (Amst)
Hoofdauteurs: Horton, Julie K., Stefanick, Donna F., Zhao, Ming-Lang, Janoshazi, Agnes K., Gassman, Natalie R., Seddon, Hannah J., Wilson, Samuel H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696015/
https://ncbi.nlm.nih.gov/pubmed/29100039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.10.007
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