An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten(+/−) mice

PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/−) mice have elev...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, Neshat, Mehran, Wang, Hong, Yang, Lin, Gibbons, Jay, Frost, Phil, Dreisbach, Valley, Blenis, John, Gaciong, Zbigniew, Fisher, Peter, Sawyers, Charles, Hedrick-Ellenson, Lora, Parsons, Ramon
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC56959/
https://ncbi.nlm.nih.gov/pubmed/11504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171060098
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars