An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten(+/−) mice

PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/−) mice have elev...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, Neshat, Mehran, Wang, Hong, Yang, Lin, Gibbons, Jay, Frost, Phil, Dreisbach, Valley, Blenis, John, Gaciong, Zbigniew, Fisher, Peter, Sawyers, Charles, Hedrick-Ellenson, Lora, Parsons, Ramon
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 2001
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC56959/
https://ncbi.nlm.nih.gov/pubmed/11504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171060098
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