An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten(+/−) mice

PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/−) mice have elev...

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Detaylı Bibliyografya
Asıl Yazarlar: Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, Neshat, Mehran, Wang, Hong, Yang, Lin, Gibbons, Jay, Frost, Phil, Dreisbach, Valley, Blenis, John, Gaciong, Zbigniew, Fisher, Peter, Sawyers, Charles, Hedrick-Ellenson, Lora, Parsons, Ramon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC56959/
https://ncbi.nlm.nih.gov/pubmed/11504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171060098
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