An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten(+/−) mice

PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/−) mice have elev...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, Neshat, Mehran, Wang, Hong, Yang, Lin, Gibbons, Jay, Frost, Phil, Dreisbach, Valley, Blenis, John, Gaciong, Zbigniew, Fisher, Peter, Sawyers, Charles, Hedrick-Ellenson, Lora, Parsons, Ramon
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC56959/
https://ncbi.nlm.nih.gov/pubmed/11504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171060098
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky