An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten(+/−) mice

PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/−) mice have elev...

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Detalhes bibliográficos
Main Authors: Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, Neshat, Mehran, Wang, Hong, Yang, Lin, Gibbons, Jay, Frost, Phil, Dreisbach, Valley, Blenis, John, Gaciong, Zbigniew, Fisher, Peter, Sawyers, Charles, Hedrick-Ellenson, Lora, Parsons, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC56959/
https://ncbi.nlm.nih.gov/pubmed/11504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171060098
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