Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

Cardiac muscle regeneration after injury is limited by “irreversible” cell cycle exit. Telomere shortening is one postulated basis for replicative senescence, via down-regulation of telomerase reverse transcriptase (TERT); telomere dysfunction also is associated with greater sensitivity to apoptosis...

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Main Authors: Oh, Hidemasa, Taffet, George E., Youker, Keith A., Entman, Mark L., Overbeek, Paul A., Michael, Lloyd H., Schneider, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC56957/
https://ncbi.nlm.nih.gov/pubmed/11517337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191169098
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