Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers. Here, we found that ectopic TERT expression increases cell proliferation, while acute reductions in TERT levels lead to a dramatic loss of proliferation without...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Khattar, Ekta, Kumar, Pavanish, Liu, Chia Yi, Akıncılar, Semih Can, Raju, Anandhkumar, Lakshmanan, Manikandan, Maury, Julien Jean Pierre, Qiang, Yu, Li, Shang, Tan, Ern Yu, Hui, Kam M., Shi, Ming, Loh, Yuin Han, Tergaonkar, Vinay
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096818/
https://ncbi.nlm.nih.gov/pubmed/27643433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86042
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