Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression

Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers. Here, we found that ectopic TERT expression increases cell proliferation, while acute reductions in TERT levels lead to a dramatic loss of proliferation without...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Khattar, Ekta, Kumar, Pavanish, Liu, Chia Yi, Akıncılar, Semih Can, Raju, Anandhkumar, Lakshmanan, Manikandan, Maury, Julien Jean Pierre, Qiang, Yu, Li, Shang, Tan, Ern Yu, Hui, Kam M., Shi, Ming, Loh, Yuin Han, Tergaonkar, Vinay
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096818/
https://ncbi.nlm.nih.gov/pubmed/27643433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86042
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