Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding

Due to the long serum half-life provided by the neonatal Fc receptor (FcRn) recycling, the IgG1 Fc has been pursued as the fusion partner to develop therapeutic Fc-fusion proteins, or as the antibody-derived scaffold that could be engineered with antigen-binding capabilities. In previous studies, we...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Wang, Chunyu, Wu, Yanling, Wang, Lili, Hong, Binbin, Jin, Yujia, Hu, Dan, Chen, Gang, Kong, Yu, Huang, Ailing, Hua, Guoqiang, Ying, Tianlei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693891/
https://ncbi.nlm.nih.gov/pubmed/29181008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01545
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