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Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding
Due to the long serum half-life provided by the neonatal Fc receptor (FcRn) recycling, the IgG1 Fc has been pursued as the fusion partner to develop therapeutic Fc-fusion proteins, or as the antibody-derived scaffold that could be engineered with antigen-binding capabilities. In previous studies, we...
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| Pubblicato in: | Front Immunol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693891/ https://ncbi.nlm.nih.gov/pubmed/29181008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01545 |
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