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Age-dependent dopaminergic neurodegeneration and impairment of the autophagy-lysosomal pathway in LRRK-deficient mice
LRRK2 mutations are the most common genetic cause of Parkinson’s disease, but its normal physiological role in the brain is unclear. Here we show that inactivation of LRRK2 and its functional homologue LRRK1 results in earlier mortality and age-dependent, selective neurodegeneration. Loss of dopamin...
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| Vydáno v: | Neuron |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693787/ https://ncbi.nlm.nih.gov/pubmed/29056298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.09.036 |
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