A Residue Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions

Characterization of interactions between proteins and other molecules is crucial for understanding the mechanisms of action of biological systems and, thus, drug discovery. An increasingly useful approach to mapping these interactions is measurement of hydrogen/deuterium exchange (HDX) using mass sp...

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Publicado en:J Phys Chem B
Autores principales: Saltzberg, Daniel J., Broughton, Howard B., Pellarin, Riccardo, Chalmers, Michael J., Espada, Alfonso, Dodge, Jeffrey A., Pascal, Bruce D., Griffin, Patrick R., Humblet, Christine, Sali, Andrej
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693600/
https://ncbi.nlm.nih.gov/pubmed/27807976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b09358
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