Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease

Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by pathology of accumulated amyloid β (Aβ) and phosphorylated tau proteins in the brain. Postmortem degradation and cellular complexity within the brain have limited approaches to molecularly define the causal relationship...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mano, Tatsuo, Nagata, Kenichi, Nonaka, Takashi, Tarutani, Airi, Imamura, Tomohiro, Hashimoto, Tadafumi, Bannai, Taro, Koshi-Mano, Kagari, Tsuchida, Takeyuki, Ohtomo, Ryo, Takahashi-Fujigasaki, Junko, Yamashita, Satoshi, Ohyagi, Yasumasa, Yamasaki, Ryo, Tsuji, Shoji, Tamaoka, Akira, Ikeuchi, Takeshi, Saido, Takaomi C., Iwatsubo, Takeshi, Ushijima, Toshikazu, Murayama, Shigeo, Hasegawa, Masato, Iwata, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692545/
https://ncbi.nlm.nih.gov/pubmed/29042514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707151114
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