PATH-29. MOLECULAR DETERMINANTS ASSOCIATED WITH RESPONSE AND RESISTANCE TO DEPATUXIZUMAB MAFODOTIN (ABT-414) IN PATIENTS WITH RECURRENT GLIOBLASTOMA

BACKGROUND: Depatuxizumab mafodotin (depatux-m, formerly ABT-414), is an EGFR-targeted antibody conjugated to the antimicrotubule agent monomethylauristatin F (MMAF). In an ongoing Phase I study, response in recurrent glioblastoma (rGBM) correlated with EGFR amplification in pre-treatment, archival...

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Published in:Neuro Oncol
Main Authors: Lassman, Andrew, Roberts-Rapp, Lisa, He, Lei, Lu, Xin, van den Bent, Martin, Papadopoulos, Kyriakos, Merrell, Ryan, Kumthekar, Priya, Reardon, David, Gomez, Erica, Fischer, JuDee, Jiang, Fang, Zha, Zheng, Bhathena, Anahita, Holen, Kyle, Ansell, Peter, Gan, Hui K, Scott, Andrew
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692486/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.719
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