PATH-29. MOLECULAR DETERMINANTS ASSOCIATED WITH RESPONSE AND RESISTANCE TO DEPATUXIZUMAB MAFODOTIN (ABT-414) IN PATIENTS WITH RECURRENT GLIOBLASTOMA

BACKGROUND: Depatuxizumab mafodotin (depatux-m, formerly ABT-414), is an EGFR-targeted antibody conjugated to the antimicrotubule agent monomethylauristatin F (MMAF). In an ongoing Phase I study, response in recurrent glioblastoma (rGBM) correlated with EGFR amplification in pre-treatment, archival...

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Publicado no:Neuro Oncol
Main Authors: Lassman, Andrew, Roberts-Rapp, Lisa, He, Lei, Lu, Xin, van den Bent, Martin, Papadopoulos, Kyriakos, Merrell, Ryan, Kumthekar, Priya, Reardon, David, Gomez, Erica, Fischer, JuDee, Jiang, Fang, Zha, Zheng, Bhathena, Anahita, Holen, Kyle, Ansell, Peter, Gan, Hui K, Scott, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692486/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.719
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