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IMMU-55. PHARMACOLOGIC INHIBITION OF PROTEIN PHOSPHATASE-2A, WITH NOVEL INHIBITOR LB-100, ACHIEVES DURABLE IMMUNE-MEDIATED ANTITUMOR ACTIVITY WHEN COMBINED WITH PD1 BLOCKADE
BACKGROUND: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase. Mounting evidences suggest that inhibition of PP2A could enhance cancer immunity. LB-100 is a novel small molecule inhibitor of PP2A that is well tolerated in a Phase I trial. We hypothesized that inhibition of PP2A may enh...
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| Udgivet i: | Neuro Oncol |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692410/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.513 |
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