IMMU-55. PHARMACOLOGIC INHIBITION OF PROTEIN PHOSPHATASE-2A, WITH NOVEL INHIBITOR LB-100, ACHIEVES DURABLE IMMUNE-MEDIATED ANTITUMOR ACTIVITY WHEN COMBINED WITH PD1 BLOCKADE

BACKGROUND: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase. Mounting evidences suggest that inhibition of PP2A could enhance cancer immunity. LB-100 is a novel small molecule inhibitor of PP2A that is well tolerated in a Phase I trial. We hypothesized that inhibition of PP2A may enh...

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Publicado no:Neuro Oncol
Main Authors: Ho, Winson SC, Wang, Herui, John, Kovach, Maggio, Dominic, Heiss, John, Gilbert, Mark R, Lu, Rongze, Zhuang, Zhengping
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692410/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.513
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