EXTH-11. PD-1 ANTAGONISM WITH CONCURRENT COMPETITIVE INHIBITION OF PP2A PROMOTES ENHANCED REGRESSION OF INTRACRANIAL GLIOBLASTOMA

BACKGROUND: Checkpoint inhibition using monoclonal antibodies against PD-1 is currently under evaluation for treatment of glioblastoma (GBM). Inhibition of protein phosphatase 2A (PP2a) was recently identified as a novel strategy to enhance cancer immunity. We hypothesized that pharmacologic inhibit...

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Pubblicato in:Neuro Oncol
Autori principali: Maggio, Dominic, Ho, Winson, Wang, Herui, Lu, Rongze, Heiss, John, Gilbert, Mark R, Zhuang, Zhengping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691937/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.306
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