TMOD-40. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS

BACKGROUND: Pediatric glioblastomas (pGBM) are characterized by overlapping and unique molecular driver mutations compared to their adult counterparts. Primary cell cultures and patient-derived xenograft (PDX) models of pGBM are rare which may contribute to difficulty in advancing patient outcomes....

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: White, Angela, Kumar, Shiva, Smith, Amanda, Ramkissoon, Annmarie, Oatman, Nicole, Dasgupta, Biplab, Breese, Erin, Stevenson, Charles, Fuller, Christine, Fouladi, Maryam, DeWire, Mariko, Drissi, Rachid, Chow, Lionel M L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692311/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1076
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