DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

INTRODUCTION: Dysregulation of the cyclin dependent kinase-retinoblastoma (CDK-RB) pathway is observed in DIPG and HGG. Ribociclib (LEE011) is an oral inhibitor of CDK4/CyclinD1 and CDK6/CyclinD3 complexes that induces RB hypophosphorylation and cell-cycle arrest. METHODS: Eligible patients with new...

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Publicat a:Neuro Oncol
Autors principals: DeWire, Mariko, Fuller, Christine, Hummel, Trent, Chow, Lionel, Salloum, Ralph, Pater, Luke, Drissi, Rachid, Lu, Qing, Stevenson, Charles, Lane, Adam, Breneman, John, Witte, David, Leach, James, Fouladi, Maryam
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011916/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.165
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