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PDTM-08. STATINS SYNGERGIZE WITH SMOOTHENED INHIBITOR VISMODEGIB TO INHIBIT MEDULLOBLASTOMA GROWTH
Activation of the hedgehog (Hh) pathway is common in basal cell carcinoma (BCC) and it occurs in approximately 30% of medulloblastoma (MB), the most common malignant pediatric brain tumor. Here, we demonstrate increased biosynthesis of cholesterol, and a requirement for cholesterol, in maintaining t...
Gorde:
| Argitaratua izan da: | Neuro Oncol |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692232/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.773 |
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