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PDTM-08. STATINS SYNGERGIZE WITH SMOOTHENED INHIBITOR VISMODEGIB TO INHIBIT MEDULLOBLASTOMA GROWTH

Activation of the hedgehog (Hh) pathway is common in basal cell carcinoma (BCC) and it occurs in approximately 30% of medulloblastoma (MB), the most common malignant pediatric brain tumor. Here, we demonstrate increased biosynthesis of cholesterol, and a requirement for cholesterol, in maintaining t...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Yang, Zeng-Jie, Gordon, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692232/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.773
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