EXTH-67. TG02, A BRAIN-PENETRANT MULTI-CDK INHIBITOR, POTENTLY SUPPRESSES MYC-DRIVEN GLIOBLASTOMA

MYC is a central driver of tumorigenesis in many malignancies, including the universally lethal glioblastoma (GBM). However, developing direct inhibitors of MYC have proven challenging. One appealing alternative strategy to target MYC-driven cancers is to interfere with the signaling program necessa...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Tsang, Jonathan, Sung, Sarah, Gosa, Laura, Meetze, Kristan, Cloughesy, Timothy, Nathanson, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692149/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.359
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