P04.11 Profound sensitivity of glioblastoma cells to apoptosis induction by TG02, a novel oral multi-cyclin-dependent kinase inhibitor

BACKGROUND: TG02 is a novel multikinase inhibitor targeting cyclin-dependent kinases (CDK) -1, -2, -5, -7 and -9 and thought to act mainly via CDK-9 inhibition-dependent depletion of short-lived oncoproteins such as MCL-1 or c-MYC. MATERIAL AND METHODS: We studied the activity of TG02 in 9 human lon...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Le Rhun, E, von Achenbach, C, Lohmann, B, Silginer, M, Schneider, H, Meetze, K, Szabo, E, Weller, M
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Poster Presentations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144666/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.245
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