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P04.11 Profound sensitivity of glioblastoma cells to apoptosis induction by TG02, a novel oral multi-cyclin-dependent kinase inhibitor
BACKGROUND: TG02 is a novel multikinase inhibitor targeting cyclin-dependent kinases (CDK) -1, -2, -5, -7 and -9 and thought to act mainly via CDK-9 inhibition-dependent depletion of short-lived oncoproteins such as MCL-1 or c-MYC. MATERIAL AND METHODS: We studied the activity of TG02 in 9 human lon...
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| Veröffentlicht in: | Neuro Oncol |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6144666/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.245 |
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