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DDIS-07. TG02, AN ORAL CDK INHIBITOR, INDUCES MULTIPLE CELL DEATH PATHWAYS IN HUMAN GLIOMA CELL LINES AND GLIOMA-INITIATING CELLS
TG02 is an orally bioavailable, multikinase inhibitor which potently inhibits cyclin-dependent kinases (CDK) 1, 2, 5, 7 and 9. CDK9-dependent depletion of short-lived oncoproteins such as MCL-1 and MYC has been proposed as its primary mechanism of cytotoxicity. Here we report that TG02 exhibits stro...
Gorde:
| Argitaratua izan da: | Neuro Oncol |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5692775/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.243 |
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