DDIS-07. TG02, AN ORAL CDK INHIBITOR, INDUCES MULTIPLE CELL DEATH PATHWAYS IN HUMAN GLIOMA CELL LINES AND GLIOMA-INITIATING CELLS

TG02 is an orally bioavailable, multikinase inhibitor which potently inhibits cyclin-dependent kinases (CDK) 1, 2, 5, 7 and 9. CDK9-dependent depletion of short-lived oncoproteins such as MCL-1 and MYC has been proposed as its primary mechanism of cytotoxicity. Here we report that TG02 exhibits stro...

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Vydáno v:Neuro Oncol
Hlavní autoři: Le Rhun, Emilie, Achenbach, Caroline Von, Szabo, Emese, Weller, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692775/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.243
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