PDTM-31. IDENTIFICATION OF PERSONALIZED ACTIVE AGENTS IN PEDIATRIC GLIOMAS THROUGH HIGH-THROUGHPUT DRUG SCREENING IN MATCHING PAIRS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT (PDOX) NEUROSPHERE AND MONOLAYER CELLS

Glioblastoma (GBM) is one of the deadliest brain tumors both in adults and children. The efficacy of targeting mutated genes/pathways has not been systematically analyzed. Matching pairs of neurosphere and monolayer cell cultures from 4 molecularly characterized PDOX mouse models established from di...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Qi, Lin, Du, Yuchen, Bae, Goeun, Kogiso, Mari, Braun, Frank, Lindsay, Holly, Zhang, Huiyuan, Zhao, Sibo, Injac, Sarah, Baxter, Patricia, Su, Jack, Mancini, Michael, Hampton, Oliver, Parsons, William, Chintagumpala, Murali, Stephan, Clifford, Davies, Peter, Li, Xiao-Nan
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691986/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.794
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