HGG-14. IDENTIFICATION OF PERSONALIZED ACTIVE AGENTS IN PEDIATRIC GLIOMAS THROUGH HIGH-THROUGHPUT DRUG SCREENING IN MATCHING PAIRS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT (PDOX) NEUROSPHERE AND MONOLAYER CELLS

Glioblastoma (GBM) is one of the deadliest brain tumors both in adults and children. The efficacy of targeting mutated genes/pathways has not been systematically analyzed. Additionally, it remains unknown if neurospheres and non-stem monolayer tumor cells will respond equally to the same target ther...

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Vydáno v:Neuro Oncol
Hlavní autoři: Qi, Lin, Du, Yuchen, Bae, Goeum, Kogiso, Mari, Braun, Frank, Lindsay, Holly, Zhang, Huiyuan, Injac, Sarah, Baxter, Patricia, Su, Jack, Mancini, Michael, Hampton, Oliver, Parsons, William, Chintagumpala, Murali, Stephan, Clifford, Davies, Peter, Li, Xiao-Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475068/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.103
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