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CSIG-09. REPROGRAMMING OF SCHWANN CELLS BY LATS1/2-TAZ/YAP SIGNALING DRIVES MALIGNANT PERIPHERAL NERVE SHEATH TUMORIGENESIS
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage derived sarcomas with poor prognosis. The molecular events underlying SC lineage cells-to-MPNST transformation remain elusive. Here, we show that human MPNSTs exhibit elevated HIPPO-TAZ/YAP expression,...
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| Publicado en: | Neuro Oncol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691965/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.204 |
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