SCDT-04. POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

Long ncRNAs (lncRNAs) have been increasingly demonstrated to affect the tumor progression via altering chromatin structure and miRNA-mediated gene regulation. We found that Notch1 activation in glioma-stem cells (GSC) specifically induces expression of the lncRNA, TUG1. TUG1 coordinately promotes se...

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Publicado en:Neuro Oncol
Main Authors: Natsume, Atsushi, Katsushima, Keisuke, Ohka, Fumiharu, Shinjo, Keiko, Miyata, Kanjiro, Kataoka, Kazunori, Kondo, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691894/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1087
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