Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier

Current antisense oligonucleotide (ASO) therapies for the treatment of central nervous system (CNS) disorders are performed through invasive administration, thereby placing a major burden on patients. To alleviate this burden, we herein report systemic ASO delivery to the brain by crossing the blood...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Min, Hyun Su, Kim, Hyun Jin, Naito, Mitsuru, Ogura, Satomi, Toh, Kazuko, Hayashi, Kotaro, Kim, Beob Soo, Fukushima, Shigeto, Anraku, Yasutaka, Miyata, Kanjiro, Kataoka, Kazunori
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317551/
https://ncbi.nlm.nih.gov/pubmed/31995252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914751
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