The Mincle ligand trehalose dibehenate differentially modulates M1‐like and M2‐like macrophage phenotype and function via Syk signaling

INTRODUCTION: Macrophages play a significant role in the progression of diseases, such as cancer, making them a target for immune‐modulating agents. Trehalose dibehenate (TDB) is known to activate M1‐like macrophages via Mincle, however, the effect of TDB on M2‐like macrophages, which are found in t...

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Udgivet i:Immun Inflamm Dis
Main Authors: Kodar, Kristel, Harper, Jacquie L., McConnell, Melanie J., Timmer, Mattie S. M., Stocker, Bridget L.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691301/
https://ncbi.nlm.nih.gov/pubmed/28722316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.186
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