Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analogue trehalose-dibehenate

The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analogue trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in antigen presenting cells. Here, we have further investigated the molecular mechanism of innate imm...

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Hauptverfasser: Schoenen, Hanne, Bodendorfer, Barbara, Hitchens, Kelly, Manzanero, Silvia, Werninghaus, Kerstin, Nimmerjahn, Falk, Agger, Else Marie, Stenger, Steffen, Andersen, Peter, Ruland, Jürgen, Brown, Gordon D., Wells, Christine, Lang, Roland
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442336/
https://ncbi.nlm.nih.gov/pubmed/20164423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904013
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