Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation

The recrystallization of an amorphous drug in a solid dispersion system could lead to a loss in the drug solubility and bioavailability. The primary objective of the current research was to use an improved kinetic model to evaluate the recrystallization kinetics of amorphous structures and to furthe...

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Pubblicato in:Drug Dev Ind Pharm
Autori principali: Feng, Xin, Ye, Xingyou, Park, Jun-Bom, Lu, Wenli, Morott, Joe, Beissner, Brad, Lian, Zhuoyang John, Pinto, Elanor, Bi, Vivian, Porter, Stu, Durig, Tom, Majumdar, Soumyajit, Repka, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690981/
https://ncbi.nlm.nih.gov/pubmed/25224341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03639045.2014.958755
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