NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated PKR translational inhibition

NLRX1 is unique among nucleotide-binding domain and leucine-rich repeat (NLR) proteins in its mitochondrial localization and capacity to negatively regulate MAVS- and STING-dependent antiviral innate immunity. However, some studies suggest a positive regulatory role for NLRX1 in inducing antiviral r...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Feng, Hui, Lenarcic, Erik M., Yamane, Daisuke, Wauthier, Eliane, Mo, Jinyao, Guo, Haitao, McGivern, David R., González-López, Olga, Misumi, Ichiro, Reid, Lola M., Whitmire, Jason K., Ting, Jenny P.-Y., Duncan, Joseph A., Moorman, Nathaniel J., Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690873/
https://ncbi.nlm.nih.gov/pubmed/28967880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3853
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