Cic loss promotes gliomagenesis via aberrant neural stem cell proliferation and differentiation

Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in ~50% of human oligodendrogliomas (OD), but mechanistic links to pathogenesis are unclear. To address this question, we generated Cic-deficient mice and human OD cell models. Genetic deficiency in mice resulted in...

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Udgivet i:Cancer Res
Main Authors: Yang, Rui, Chen, Lee H., Hansen, Landon J., Carpenter, Austin B., Moure, Casey J., Liu, Heng, Pirozzi, Christopher J., Diplas, Bill H., Waitkus, Matthew S., Greer, Paula K., Zhu, Huishan, McLendon, Roger E., Bigner, Darell D., He, Yiping, Yan, Hai
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690824/
https://ncbi.nlm.nih.gov/pubmed/28939681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1018
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